Here, we present evidence that S100A8/A9 actives the downstream genes associated with Mitogen-activated protein kinases (MAPK) and NF-kB signaling pathways to promote tumor growth and metastasis and the expression of S100A8/A9 on myeloid cells is also essential for development of colon tumors in mice model [75]. This evidence concerns the gene S100A8 and colonic neoplasm.