DPP4 and Hyperglycemia: Saxagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that inhibits degradation of the incretin hormones glucagon-like peptide-1 and glucose-dependent insulinotropic peptide, complementing the actions of metformin by reducing postprandial hyperglycemia, enhancing insulin secretion, and inhibiting paradoxical increased postprandial glucagon secretion [1,8].