Regarding metabolism, mTOR’s central role comes directly into play because activated lymphocytes primarily use glycolysis for energy due to their need to produce proteins, nucleotides and lipids that are essential for the generation of key biosynthetic substrates [11,12]; the shifting from mitochondrial respiration to glycolysis (referred to as the Warburg effect) is similar to that which occurs in cancer cells. Here, MTOR is linked to cancer.