CDH1 and adenocarcinoma: For example, earlier we have reported that in TRAMP (transgenic adenocarcinoma of the mouse prostate) mice E-cadherin expression is lost while SNAI1 expression is increased with disease progression from PIN to poorly differentiated adenocarcinoma stages [70]; and the administration of the cancer chemopreventive agent Silibinin, a natural flavonoid from Milk thistle extract, strongly enhanced E-cadherin expression while it decreased SNAI1 expression and prevented PCA metastasis to distant organs [70].