Therefore, E-cadherin and SNAI1 are important in the clinical progression of the disease; and in the present study, we demonstrate the role of E-cadherin and SNAI1 in conferring several aggressive characteristics to PCA cells such as higher proliferation rate, clonogenicity, stemness and increased expression of biomarkers for stemness, EMT, and metastasis. Here, SNAI1 is linked to posterior cortical atrophy.