Importantly, we found that the restoration of miR-26b expression significantly inhibited the phosphorylation of IκBα and p65, reduced the NF-κB reporter activity, blocked the nuclear translocation of NF-κB, consequently abrogated the expression of anti-apoptosis genes and sensitized HCC cells to the doxorubicin-induced apoptosis in HCC cells. This evidence concerns the gene RELA and hepatocellular carcinoma.