TP53 and cancer: Among the rest of pathways shown in Table 3 five of them were thought to be cancer-related, which include "Cytokine-cytokine receptor interaction" [25], "p53 signalling pathway"[26], "Apoptosis", "Natural killer cell mediated cytotoxicity" [27], "Wnt signalling pathway" [28]" and "Notch signalling pathway" [29].