In the GBM data, the involved pathways include parts of the RB signaling and RTK signaling pathways (CDKN2B, CDK4; EGFR, NF1 ), and in the ovarian carcinoma data a recurrent mutated module related to cell cycle and DNA repair (CCNE1, MYC, RAD52 ) is revealed. This evidence concerns the gene RB1 and ovarian carcinoma.