CSF2 and familial pancreatic carcinoma: Gjertsen et al. vaccinated 38 patients who had advanced pancreatic cancer with a mixture of 4 mutant ras peptides reflecting the substitution of Gly at position 12 with an Asp, Cys, Val or Arg residue in combination with GM-CSF and reported a median OS of 2.7 months and peptide-specific immunity of 58% as measured by DTH and T-cell response [13].