CD4 and neoplasm: The scFvMTBHsp70/tumor cell-pulsed DCs induced significantly higher production of IFN-γ and Granzyme B from both CD4+ and CD8+ tumor cell-primed T cells as compared with MTBHsp70 or PBS, indicating that scFvMTBHsp70 enhances tumor antigen presentation and cross-presentation by DCs (Figure 4C and D).