Besides, a number of signaling pathways well known to play a crucial role in cancer progression were only observed in isoform signatures, including ErbB signaling pathway, MAPK signaling pathway, Insulin signaling pathway, Wnt signaling pathway, VEGF signaling pathway, etc. These results suggest that isoform signatures provide additional insight into the biological mechanisms related to the tumor progression. The gene discussed is EGFR; the disease is neoplasm.