These isoforms are useful for separating cancer stages and are enriched in a number of critical biological function and pathways associated with cancer progression and metastasis, such as adherens and tight junctions, ErbB signaling, MAPK signaling, VEGF signaling pathways, etc. Furthermore, the expression abundance of a number of isoforms is significantly associated with the increased risk of death in an independent dataset. This evidence concerns the gene VEGFA and cancer.