Our study cohort consisted of patients with PCOS, who were generally overweight or obese (mean BMI 30.3 ± 9.0 kg/m2) but who had relatively low serum levels of LH levels (7.9 ± 4.4 IU/L) and normal markers of hyperandrogenism (TT 0.36 ± 0.13 nmol/L, FTc 5.0 ± 3.6 pmol/L and SHBG 74.6 ± 59.1 nmol/L). This evidence concerns the gene SHBG and polycystic ovary syndrome.