TNF and colon carcinoma: A decrease observed in macrophage migration inhibitory factor (MIF) serum level in healthy volunteers consuming Chicory coffee [19] and an inhibition in the expression and activity of COX-2 by the ethyl acetate root extract in human colon carcinoma HT29 cells treated with the pro-inflammatory cytokine TNF-α are further evidences implying the effectiveness of this plant on modulation of immune mediators release [1].