TP53 and cancer: We identified 28 KEGG pathways for trisomy 8, 19 KEGG pathways for trisomy 13, 23 KEGG pathways for trisomy 22, and 18 KEGG pathways for monosomy X. There are nine pathways appeared in all four aneuploid cell lines: axon guidance, calcium signaling, focal adhesion, ribosome, MAPK signaling pathway, p53 signaling pathway, vascular smooth muscle contraction, pathways in cancer and basal cell carcinoma (Figure 6).