In this study, first, we performed a comprehensive assessment of the potential function of PCa related SNPs, utilizing the Encyclopedia of DNA Elements (ENCODE) genomic annotation databases, the annotation systems from University of California Santa Cruz database (UCSC table browser; http://genome.ucsc.edu/), and knowledge of PCa specific transcription factor binding sites (TFBS), e.g., AR, ER, and FoxA1, defined by previous studies [50,51]. The gene discussed is ESR1; the disease is posterior cortical atrophy.