To better describe the importance of collected PCa genes, we highlighted the edges connecting critical nodes in this network, such as IGF-2, IGF-1, IRS-1, INS, STAT1, CREB1, STAT3, STAT5, c-Myc and Tcf. Moreover, we used GeneGO to conduct the statistical analysis to identify the important interactions, hubs, transcription factors, and receptors, which was listed in Additional file 6 (note, there were different sheets in Additional file 6). The gene discussed is CREB1; the disease is posterior cortical atrophy.