Our method shows its potential therapeutic use in CD through acting on multiple targets HSP90AA1 and FPR1, affecting multiple pathways NOD-like receptor signaling pathway and staphylococcus aureus infection pathway, and further affecting multiple CD mechanism genes IL6, TNF, NLRP3, NOD2, FPR2 and IL10. Here, IL10 is linked to staphylococcus aureus infection.