The most repetitive keywords are "Metabolism" and "PID_HNF3BPATHWAY" (transcription factor network of FOXA2 and FOXA3), hinting that the function of metabolism regulation and the potential for differentiation were abnormal in HCC, because FOXA2 (forkhead box A2 [57]) and FOXA3 (forkhead box A3 [58]) are hepatocyte nuclear factors that act as transcriptional activators for liver-specific genes such as albumin and transthyretin. The gene discussed is FOXA3; the disease is hepatocellular carcinoma.