Based on the hypothesis that interactions of miRNA-TF-miRNA or TF-miRNA-TF-miRNA targets represent miRNA-miRNA interactions, we used gene enrichment based on the top targets of miRNAs common to NSCLC and SCLC in Osprey to create a protein-protein interaction map (Figure 1, Steps-6-7). Here, TF is linked to non-small cell lung carcinoma.