We found that E2F6, HMGA1, IRF1, and TFDP1 were upregulated and RBL1, SUV39H1, and HNRPD were downregulated or aberrantly expressed in adenocarcinoma and squamous cell carcinoma, which are the sub-types of NSCLC. The gene discussed is IRF1; the disease is squamous cell carcinoma.