In AML, the only increased risk association was observed among non-white MLL-r cases with the ARID5B rs10821936 mutant genotype (OR 4.82, 95% CI: 1.50-15.50), while the CEBPE variant allele was negatively associated with MLL-germline AML (OR 0.22, 95% CI: 0.07-0.72) (Additional file 3: Table S3). This evidence concerns the gene KMT2A and acute myeloid leukemia.