However, as our data support, CRP levels are positively associated with several established cardiovascular risk factors, including high blood pressure, atherogenic dyslipidaemia, high BMI, diabetes mellitus, metabolic syndrome and smoking, and are low in individuals with protective factors, including high levels of physical activity, high HDL-C and apolipoprotein A1 levels, and consumption of fruits and vegetables [27-32]. The gene discussed is CRP; the disease is hypertensive disorder.