Since PKC is involved in a number of physiological processes, its upregulation contributes to the pathogenesis of diabetic retinopathy in the form of differential synthesis of extracellular matrix (ECM) proteins and ECM remodelling, enhanced release of angiogenic factors, endothelial and leukocyte dysfunction leading to capillary occlusion and leukostasis, and changes in blood flow to the retina. The gene discussed is PRRT2; the disease is diabetic retinopathy.