When these patients were stratified into those with tumours containing detectable proline-hydroxylated HIF-1α versus those with HIF-1α without hydroxylation, patients with primary tumours containing hydroxylated HIF-1α had significantly worse overall survival than patients with tumours without detectable HIF-1α (7.06 vs. 8.63 years, p = 0.040) (Figure 5B and Supporting Tables S3 and S4 in File S1). Here, HIF1A is linked to neoplasm.