Subsequent antiangiogenic agent FDA approvals include the multitargeted pan-VEGF receptor (VEGFR) tyrosine kinase inhibitors (TKIs) that target different parts of the angiogenic pathway: sorafenib for the treatment of advanced RCC and unresectable hepatocellular carcinoma; sunitinib for metastatic RCC, gastrointestinal stromal tumor, and advanced pancreatic neuroendocrine tumors; pazopanib for metastatic RCC and advanced soft tissue sarcoma (with orphan drug status designation for this indication); vandetanib for advanced medullary thyroid cancer; and axitinib for advanced RCC. This evidence concerns the gene KDR and renal cell adenocarcinoma.