PNPLA3 and obesity due to melanocortin 4 receptor deficiency: Two recent studies observed that the PNPLA3 rs738409 GG-genotype associated with lower serum triglyceride and cholesterol levels among obese (Palmer et al. 2012) or glucose-intolerant individuals (Krarup et al. 2012) and was suggested to be a result of an obesity-driven reduced triglyceride hydrolysis and intrahepatic fat accumulation (Pirazzi et al. 2012).