In this study, we examine interaction between PNPLA3 rs738409 and overweight on fasting blood triglyceride and serum alanine aminotransferase (ALT) levels and challenge the question if rs738409 interacts with dietary intakes of CHO, sucrose or ω-6:ω-3 PUFA ratio, on fasting triglyceride levels in adult Swedes participating the Malmö Diet and Cancer Study-Cardiovascular Cohort (MDCS-CC). Here, GPT is linked to cancer.