A common missense variation Ile148Met (rs738409, G-allele), in the patatin-like phospholipase domain-containing protein 3 gene (PNPLA3), also named adiponutrin, was identified associated with liver fat content and non-alcoholic fatty liver disease (NAFLD) in a genome-wide association study (GWAS) in 2008 (Romeo et al. 2008). Here, PNPLA3 is linked to metabolic dysfunction-associated steatotic liver disease.