PNPLA3 and Hepatic steatosis: Finally, the presence of the 148M allele in children treated with docosahexaenoic acid (22:6 ω-3) worsened the beneficial reduction induced by this fatty acid on hepatic steatosis (Nobili et al. 2013), and in obese adolescents, the oxidized fatty acids derived from linoleic acid associated with markers of liver injury only in PNPLA3 risk-genotype carriers (Santoro et al. 2014).