CD177 and neoplasm: Therefore, the prominent roles of these matricellular proteins in inflammatory responses, tumor dormancy and metastasis are to remodel the biophysical and biochemical properties of tissue microenvironment; recruit Wnt, Notch, TGF-β or other ligands to modulate their signaling; and bind with their cell surface receptors to regulate survival- and proliferation-related pathways inside the cells by interacting with growth factors, proteases, cell surface receptors and other structural matrix proteins, as well as themselves.