Matricellular proteins are a set of non-structural extracellular matrix (ECM) proteins, mainly including thrombospondins (TSPs), OPN, tenascins, SPARC, POSTN and CCNs, which do not exert a primary role in tissue architecture but regulate similar biological functions in response to external stimuli during embryonic development, tissue injury, inflammation and tumor progression (Bornstein, 1995). This evidence concerns the gene TNC and neoplasm.