After adjustment for age, sex, and WAA, the A allele of SNP rs12794714, located in the 25-hydroxylase gene CYP2R1, was associated with a decreased risk of CRC in the combined CRC groups (p = 0.019; OR = 0.79, 95 % CI 0.65–0.96). Here, CYP2R1 is linked to colorectal carcinoma.