FOXP3 and breast neoplasm: Foxp3 expression in breast tumor has been associated with lower probability of overall survival (OS), with increasing intensity of Foxp3 immunostaining.26 Foxp3 was also a strong prognostic factor for distant metastasis-free survival, but not local recurrence risk.26 The clinical significance of tumor infiltrating Foxp3-positive Tregs has been assessed in breast cancer patients with long-term follow-up.