CD276 and malignant colon neoplasm: In contrast, other groups reported that treatment by intratumoral injection of an adenovirus-expressing mouse B7-H3 (Ad-B7-H3-GFP) resulted in a reduction of tumor size compared with control animals in the orthotropic murine colon cancer model.16 As a result, B7-H3 appears likely to exert both stimulatory and inhibitory immunological functions.