B7-H3 expression has been found in a variety of human malignancies, including breast, prostate, non-small cell lung, pancreatic, gastric, endometrial, and colorectal cancers.6–8,10,12,17,31–34 It was reported that B7-H3 expression by breast cancer cells are a potential tumor progression factor that is a predictor of early regional nodal metastasis.17 Here, CD276 is linked to breast cancer.