INS and Insulin resistance: Japanese type 2 diabetic patients carrying the T allele of this SNP showed a significantly lower intima media thickness (IMT) and lower 8-hydroxy-2′-deoxyguanosine (8-OHdG) values (not significant), whereas the non-diabetic T allele carriers were protected against insulin resistance, exhibiting lower HOMA-IR and fasting plasma insulin values [86].