The impact of PRDX3 genetic variations on obesity has been investigated in only one nutrigenomic study, in which it was found that four SNPs in the PRDX3 gene and the haplotype they formed were associated with higher BMI and obesity in Japanese people, when combined with a high-fat diet (HFD) [69] (Figure 2, Table 2). The gene discussed is PRDX3; the disease is obesity due to melanocortin 4 receptor deficiency.