PIK3CA and cancer: Subgroup analysis of AKT phosphorylation in tumors without PIK3CA mutations (18 CCC and 12 EC) showed statistically significant increases in both pAKT-Ser473 and pAKT-Thr308 for 8 cancers lacking BAF250a expression on IHC (p = 0.05 and 0.008 respectively; t-test).