CXCR4 and metastatic malignant neoplasm in the lymph nodes: Moreover, the expression of several chemokine receptors has been associated with a greater risk of developing regional and distant metastases[7,8] as lymph node metastasis (CCR7[13]; CCR10,[14]; CXCR3 and CXCR4;[15]), pulmonary metastasis (CXCR4) or skin metastasis (CCR10;[13]).