The aim of this work was to characterize the secretion and the intracellular expression of the chemokines CXCL9, CXCL10, CXCL11, CXCL12, CCL19, CCL21, CCL27 and CCL28 and the surface and intracellular expression of their chemokine receptors CXCR3, CXCR4, CXCR7, CCR7 and CCR10 in human melanoma cell lines, and the effect of xenotransplantation on the chemokine/chemokine receptor expression. The gene discussed is CCL21; the disease is melanoma.