Pathological findings include generalized cortical atrophy, cavum septum pellucidum, extensive neurofibrillary tangles (NFTs) and astrocytic tangles composed of mixed 3-repeat (3R) and 4-repeat (4R) tau isoforms in the frontal and temporal cortices, often patchy and irregular, with predilection for perivascular regions[4] and in the depths of cerebral sulci with NFTs in the limbic regions, diencephalon and brainstem[5] but, in contrast to Alzheimer’s disease (AD), there is relatively little amyloid-β deposition (Aβ)[4-7]. Here, MAPT is linked to Alzheimer disease.