Taking into consideration the patient's physical symptoms, poor kidney function (creatinine > 5 mg/dL and urea > 200 mg/dL), severe anemia (Hb 7.0 g/dL), thrombocytopenia (60 × 103/μL), and fragmented red blood cells on peripheral smear, a diagnosis of hemolytic-uremic sdyndrome (HUS) was established. The gene discussed is GSTM1; the disease is Thrombocytopenia.