Melanoma cell lines previously demonstrated to contain high endogenous amounts of Dsg2, i.e., MeWo cells derived from a lymph node metastasis and C32 cells from a primary amelanotic melanoma [21], were depleted of Dsg2 using siRNA techniques and compared to their Dsg2-rich counterparts treated with non-targeting siRNA. Here, DSG2 is linked to melanoma.