In addition to CRC, abnormal expression of NNMT was also reported in other tumors such as papillary thyroid cancer [10], glioblastoma [11], gastric cancer [12], [13], renal carcinoma [14]–[16], oral squamous cell carcinoma [17], [18], lung cancer [19], pancreatic cancer [20], [21] and ovarian clear cell carcinoma [22]. The gene discussed is NNMT; the disease is renal carcinoma.