S100A8 and glomerulosclerosis: By univariate analysis, glomerular and/or tubulointerstitial MRP8 protein expression was significantly correlated to age, systolic and diastolic blood pressures, urinary protein, serum levels of creatinine, BUN and HDL cholesterol, eGFR, and extent of global glomerulosclerosis and tubulointerstitial fibrosis.