However, we have compared CD4+LAP+ Tregs levels between patients with and without ongoing treatment with clopidogrel, β—blockers, statins, angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, or nitrate, and these factors did not influence CD4+LAP+ Tregs expression use multivariate analysis, moreover, as shown previously, the circulating CD4+LAP+ Tregs levels were also not correlated with hypertension (data not shown) [48]. This evidence concerns the gene CD4 and hypertensive disorder.