The results suggested that Fas -1377 G/A polymorphism was overall associated with cancer susceptibility (additive model: OR, 1.16, 95%CI = 1.06–1.27, Pheterogeneity  = 0.381; recessive model: OR, 1.19, 95%CI = 1.10–1.29, Pheterogeneity  = 0.137). The gene discussed is FAS; the disease is cancer.