Extensive studies have demonstrated that the use of aspirin significantly reduced the occurrence of CAD [21], [22], and it has been proposed that the efficacy of aspirin to reduce the occurrence of CAD was related not only to the ability of the compound to inhibit platelet cyclooxygenase [23], [24], but also to the thrombolytic effect of the compound due to NO synthesis leading to plasmin formation [25]. The gene discussed is PLG; the disease is coronary artery disorder.