We found that GPR15 expression was up-regulated ex vivo on CD4+ T cells in two out of eleven HIV-1 patients, that HIV-1 infection can upregulate GPR15 in PM1 T cells and that TLR3 triggering by dsRNA [46] up-regulated GPR15 expression on CD4+ T cells. The gene discussed is TLR3; the disease is HIV-1 infection.