Systemic infusion with MSCs also mediated a down-regulation of proinflammatory (TNF-α and IFN-γ) in several animal model including endotoxin-induced acute lung injury mice model, experimental autoimmune encephalomyelitis (EAE) and ischemia-reperfusion-induced severe acute renal failure model [41]–[43]. This evidence concerns the gene TNF and experimental autoimmune encephalomyelitis.