When we restricted analysis to children who had a clinically normal CRP value (<5 mg/L), to exclude those with intercurrent infections driving an acute phase response at the time of sample collection, we found the same negative correlation between CRP and IGF-1 (at 6 w, R = −0.23, P = 0.011; at 3 mo, R = −0.44, P<0.001). This evidence concerns the gene CRP and infection.