In summary, we suggest that the simultaneous presence of protein-coding sequence variants in ATP7B and PRNP in a patient with neurological Wilson’s disease constitutes a serendipitous biological “experiment of nature” that will be of interest both to clinicians from a diagnostic perspective, and also to basic scientists interested in the (patho)physiologic functions of ATP7B and PrP, including potential biochemical or metabolic synergistic effects mediated by copper metabolism of the human brain. This evidence concerns the gene PRNP and Wilson disease.