Promotes neuronal transcriptome/neurogenesis; inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells, regulation of renin-angiotensin-aldosterone system, radiosensitize Glioblastoma multiforme cells, promotes neuronal survival under ischemic conditions, induce differentiation into neurons, regulates the migration of glioma cells and the self-renewal of GSCs, inhibits growth of medulloblastoma xenograft tumors, regulates neuroblast proliferation, alleviates cell death. This evidence concerns the gene REN and glioblastoma.