In addition, a number of growth factors and cytokines, for example, the Insulin-like growth factor (IGF), Insulin, Hedgehog (Hh), transforming growth factor (TGF-β), and the Advanced Glycation End products (AGEs) are overexpressed in the microenvironment of pancreatic cancer cells, leading to uncontrolled cancer cell proliferation, unorganized angiogenesis and evasion of apoptosis. This evidence concerns the gene IGF1 and familial pancreatic carcinoma.