This data is supporting by recent discoveries that AMPK activation play a critical role in inhibiting cancer metastasis: (a) Taliaferro-Smith et al. demonstrated that AMPK activation by adiponectin inhibits the migration of breast cancer cells [42]; (b) Kin et al. indicated that berberine increases AMPK activity and hence decreases the migration of melanoma cells [20]; (c) Park et al. also demonstrated that berberine inhibits colon cancer migration by activating AMPK [21]. The gene discussed is ADIPOQ; the disease is melanoma.