The translocation of p53 to the mitochondria by alterations in the activity of Bax induces cytochrome c release to the cytosol of neuronal cells after global brain ischemia (Xiang et al. 1998; Sugawara et al. 1999; Cao et al. 2001; Mihara et al. 2003; Hong et al. 2010). This evidence concerns the gene CYCS and brain ischemia.