Therefore, colon cancer HCT116 cells were employed to evaluate the potential chemotherapeutic effect of Chel A. Briefly, our results found that Chel A was capable of activating p53-mediated apoptosis in HCT116 cells, which in turn resulted in the inhibition of anchorage-independent growth of HCT116 cells. This evidence concerns the gene TP53 and malignant colon neoplasm.