In EC-109 cells (Figure 1B), the suppression of cells by infection with replication-competent adenoviruses (Ad-CMV-E1a, Ad-hTERT-E1a, Ad-CMV-E1a-HN and Ad-hTERT-E1a-HN) increased significantly over the infection time, especially in those infected with Ad-CMV-E1a-HN or Ad-hTERT-E1a-HN. Here, DHTKD1 is linked to infection.