DHTKD1 and neoplasm: Here, we combined the tumor-specific apoptosis-inducing gene encoding HN and a cancer-specific human telomerase reverse transcriptase promoter (hTERT) with a RAPAd.I adenovirus vector to construct a novel dual-specific anti-tumor oncolytic adenovirus Ad-hTERT-E1a-HN, as well as the control recombinant adenoviruses Ad-mock, Ad-CMV-E1a, Ad-hTERT-E1a, Ad-CMV-HN, Ad-hTERT-HN and Ad-CMV-E1a-HN.