ACTR3 and cancer: As the concentration of CDDO-Me increases, it targets Actin-related protein 3 (Arp3) and other components of the cytoskeleton to inhibit cell proliferation, whereas even higher concentrations (micromolar) of CDDO-Me can selectively induce apoptosis in cancer cells by targeting a number of key regulatory proteins and pathways that are frequently constitutively activated or overexpressed in cancer cells [5].