INS and diabetes mellitus: Severe maternal diseases of the cardiovascular and pulmonary systems (severe pulmonary hypertension, heart failure, aortic and mitral valve defects or widening of the ascending aorta in connection with Marfan syndrome), insulin obligatory diabetes, addictive disorders (alcohol, drugs) as well as chronic intrauterine infections (with CMV, HSV, HIV or toxoplasmosis) are indicative of a high risk pregnancy [6].