Detailed biochemical studies of steroid hormone receptor cross-talk are needed to provide a framework for a better understanding of differential hormone actions in pre- and post-menopausal conditions where endogenous hormone levels dramatically differ, as well as during breast or prostate cancer treatment with hormone-ablation therapies where closely related steroid hormone receptors (PR, GR, AR, ER) may substitute for the blocked activity of another (ER or AR). Here, AR is linked to prostate cancer.